In the NKJV, Mark 16:18 reads like this: “they will take up serpents; and if they drink anything deadly, it will by no means hurt them; they will lay hands on the sick, and they will recover.”*

The NIV renders ‘they will pick up snakes with their hands’, the ‘with their hands’ being based on just over 2% of the Greek manuscripts. As we know, there are those who take this translation literally, and believe that they must handle poisonous snakes in obedience to God. I respect their sincerity, but believe they have been misled by a faulty translation.

I would say that this particular statement of the Lord's has been generally misunderstood. The verb in question covers a wide semantic area, one of the uses being to pick up the way a garbage man picks up a bag of trash—he does so to get rid of it (hence ‘remove’). I believe Luke 10:19 sheds light on this question. In Luke 10:19 the Lord Jesus said: “Behold, I give [so 98% of the Greek manuscripts] you the authority to trample on snakes and scorpions, and over all the power of the enemy, and nothing shall by any means hurt you.” The Lord is addressing the Seventy, not the Twelve, and others were doubtless present; further, this was said perhaps four months before His death and resurrection. It follows that this authority is not limited to the apostles, and there is no indication of a time limit. The Lord Jesus affirms that He gives us the authority over all the power of the enemy. In Matthew 28:18 He declares that He holds “all authority… in heaven and earth”, and so He has the right and the competence to delegate a portion of that authority to us. We may have any number of enemies, but the enemy is Satan. The phrase, “all the power”, presumably includes his works, followed by their consequences.

Returning to Luke 10:19, the Lord gives us the authority to “trample snakes and scorpions”. Well now, to smash the literal insect, a scorpion, you don't need power from on High, just a slipper (if you are fast you can do it barefoot). To trample a snake I prefer a boot, but we can kill literal snakes without supernatural help. It becomes obvious that Jesus was referring to something other than reptiles and insects. I understand Mark 16:18 to be referring to the same reality—Jesus declares that certain signs will accompany the believers (the turn of phrase virtually has the effect of commands): they will expel demons, they will speak strange languages, they will remove ‘snakes’, they will place hands on the sick. (“If they drink…” is not a command; it refers to an eventuality.) But what did the Lord Jesus mean by ‘snakes’?

In a list of distinct activities Jesus has already referred to demons, so the ‘snakes’ must be something else. In Matthew 12:34 Jesus called the Pharisees a ‘brood of vipers’, and in 23:33, ‘snakes, brood of vipers’. In John 8:44, after they claimed God as their father, Jesus said, “You are of your father the devil”. And 1 John 3:10 makes clear that Satan has many other ‘sons’. In Revelation 20:2 we read: “He seized the dragon, the ancient serpent, who is a slanderer, even Satan, who deceives the whole inhabited earth, and bound him for a thousand years.” If Satan is a snake, then his children are also snakes. So then, I take it that our ‘snakes’ are human beings who chose to serve Satan, who sold themselves to evil. I conclude that the ‘snakes’ in Luke 10:19 are the same as those in Mark 16:18, but what of the ‘scorpions’? Since they also are of the enemy, they may be demons, in which case the term may well include their offspring, the humanoids [see my paper, “In the Days of Noah”, available from my site: prunch.org]. I am still working on the question of just how the removal is to be done.